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Research Publications


Embryos at Blastocyst Stage
At the Fertility Center of Las Vegas, our philosophy is to stimulate optimally, trigger safely, and transfer your best embryos into an ideally prepared uterus. While these principles may seem obvious, extensive research was needed to determine how to achieve these goals. We continue to improve the best practices of fertility medicine.

 


Blastocyst EmbryoTransfer Research Publications

Large blastocyst diameter, early blastulation, and low pre-ovulatory serum progesterone are dominant predictors of clinical pregnancy in fresh autologous cycles.
Bruce S. Shapiro, Said T. Daneshmand, Forest C. Garner, Martha Aguirre, Shyni Thomas. Fertility and Sterility. In Press.

Contrasting patterns in in vitro fertilization pregnancy rates among fresh autologous, fresh oocyte donor, and cryopreserved cycles with the use of day 5 or day 6 blastocysts may reflect differences in embryo-endometrium synchrony.
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R.
Fertility & Sterility. 2008.

Blastocyst diameter, day of blastulation, and pre-ovulatory serum progesterone simultaneously correlate with clinical pregnancy after blastocyst transfer.
Shapiro, B.S.; Daneshmand, S.T.; Garner, F.C.; Aguirre, M.; and Thomas, S. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, Lyon, France, 2007.

Comparing Day 5 and Day 6 Blastocyst Transfers in Fresh Autologous, Frozen Autologous, and Fresh Oocyte Donor Cycles
B. S. Shapiro, S. T. Daneshmand, F. C. Garner, M. Aguirre, R. Ross.
06-A-434-ASRM

Granulocyte-macrophage colony-stimulating factor enhances human embryo development to the blastocyst stage: a randomized study
Shapiro BS, Richter KS, Daneshmand ST, Quinn P, Behr B
Fertility and Sterility- 2003 04 (Vol. 79, Issue (Supplement 2))

Vero cell coculture with sequential blastocyst media: a randomized controlled study comparing two different cleavage-stage media formulations
Shapiro BS, Richter KS, Harris DC, Daneshmand ST
Fertility and Sterility- 2002 04 (Vol. 77, Issue (Supplement 3))

Quantitative grading of a human blastocyst: optimal inner cell mass size and shape.
Richter KS, Harris DC, Daneshmand ST, Shapiro BS.
Fertility and Sterility. 2001 Dec;76(6):1157-67.

A comparison of day 5 and day 6 blastocyst transfers.
Shapiro BS, Richter KS, Harris DC, Daneshmand ST.
Fertility and Sterility. 2001 Jun;75(6):1126-30.

Predictive value of 72-hour blastomere cell number on blastocyst development and success of subsequent transfer based on the degree of blastocyst development.
Shapiro BS, Harris DC, Richter KS. Fertility and Sterility. 2000 Mar;73(3):582-6.


Elimination of Ovarian Hyper-Stimulation Syndrome Research Publications


Gonadotropin releasing hormone agonist combined with a reduced dose of human chorionic gonadotropin for final oocyte maturation in fresh autologous cycles of in vitro fertilization.
Bruce S. Shapiro, M.D., Said T. Daneshmand, M.D., Forest C. Garner, M.S., Martha Aguirre, Ph.D., and Shyni Thomas, B.S. Fertility and Sterility In Press.

Comparison of human chorionic gonadotropin and gonadotropin-releasing hormone agonist for final oocyte maturation in oocyte donor cycles.
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R. Fertility and Sterility July, 2007 (Vol. 88, Issue 1, 237-9).

Cumulative pregnancy rates when using GnRH agonist instead of hCG for final oocyte maturation
S. T. Daneshmand, B. S. Shapiro, F. C. Garner, M. Aguirre, R. Ross.
06-A-1468-ASRM

Eliminating Severe Ovarian Hyperstimulation Syndrome By Using GnRH Agonist Instead of HCG
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R
Fertility and Sterility- 2005 04 (Vol. 83, Issue 5 (Supplement))

Effects of the ovulatory serum concentration of human chorionic gonadotropin on the incidence of ovarian hyperstimulation syndrome and success rates for in vitro fertilization.
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R, Morris S.
Fertility and Sterility 2005 Jul;84(1):93-8.

Low serum HCG concentrations following the ovulatory dose of HCG are not associated with reduced IVF success rates
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R, Morris S.
Fertility and Sterility- 2004 04 (Vol. 81, Issue (Supplement 3))

Comparison of human chorionic gonadotropin and gonadotropin-releasing hormone agonist for final oocyte maturation in oocyte donor cycles.
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R. Fertil Steril. 2007 Jul;88(1):237-9.

Including a low dose of hCG along with GnRH agonist “trigger” reduces early pregnancy loss rates when compared to the agonist alone.
BS Shapiro, ST Daneshmand, FC Garner, M Aguirre, S Thomas. Accepted for: 63rd Annual Meeting of the American Society for Reproductive Medicine, Washington D.C. October, 2007.

 

Transfer of Previously Frozen / Thawed Blastocysts Research Publications


Improved Survival and Pregnancy Rates with Transfer of Cryopreserved Blastocysts
S. T. Daneshmand, B. S. Shapiro, F. C. Garner, M. Aguirre, R. Ross.
06-A-406-ASRM

Improved Survival and Implantation Rates for Thawed Embryos
Aguirre M, Shapiro BS, Daneshmand ST, Garner FC, Ross R
Fertility and Sterility- 2005 04 (Vol. 83, Issue 5 (Supplement))

Cumulative IVF Pregnancy Rates After Fresh and Frozen Embryo Transfer
Daneshmand ST, Shapiro BS, Garner FC, Aguirre M, Ross R
Fertility and Sterility- 2005 04 (Vol. 83, Issue 5 (Supplement))